The Threshold of Toxicological Concern for prenatal developmental toxicity in rats and rabbits
نویسندگان
چکیده
منابع مشابه
Chemical Similarity and Threshold of Toxicological Concern
There are many national, regional and international programmes – either regulatory or voluntary – toassess the hazards or risks of chemical substances to humans and the environment. The first step inmaking a hazard assessment of a chemical is to ensure that there is adequate information on each of theendpoints. If adequate information is not available then additional data is nee...
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Historical control data on rabbit prenatal developmental toxicity studies, performed between 1994-2010, were obtained from 20 laboratories, including 11 pharmaceutical and chemical companies and nine contract laboratories, in Japan. In this paper, data were incorporated from a laboratory if the information was based on 10 studies or more. Japanese White rabbits and New Zealand White rabbits wer...
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15 صفحه اولThe Threshold of Toxicological Concern (TTC) in risk assessment.
The Threshold of Toxicological Concern (TTC) is a level of human intake or exposure that is considered to be of negligible risk, despite the absence of chemical-specific toxicity data. The TTC approach is a form of risk characterisation in which uncertainties arising from the use of data on other compounds are balanced against the low level of exposure. The approach was initially developed by t...
متن کاملthe effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
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ژورنال
عنوان ژورنال: Regulatory Toxicology and Pharmacology
سال: 2017
ISSN: 0273-2300
DOI: 10.1016/j.yrtph.2017.06.008